Acetyl-l-Carnitine Supplement. Aceryl-l Carnitine and Alpha lipoic Acid information
Mind Power Rx with Acetyl-l-carnitine brain booster

What is Acetyl l Carnitine?
Acetylcarnitine (also spelled as acetyl l carnitine, acetyl-l carnitine, or l-acetylcarnitine and abbreviated as ALC or ALCAR) and carnitine play several important roles in the human body. These nutrients shuttle acetyl groups and fatty acids into mitochondria for energy production. Without carnitine, fatty acids cannot easily enter into mitochondria. The acetyl group of acetyl l carnitine is used to form acetyl-CoA, the most important intermediary in the generation of energy from amino acids, fats, and carbohydrates. Therefore, acetyl l carnitine serves as an energy reservoir of acetyl groups and both acetylcarnitine and carnitine help improve energy production. The acetyl group of acetyl l carnitine is also used to make the important brain chemical acetylcholine. Some studies suggest that perhaps acetyl l carnitine can even act as a neurotransmitter itself.

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Mind Power Rx with Acetyl-l-Carnitine is a sophisticated cognitive formula. It combines a delicate balance of brain circulation agents and neurotransmitter precursors with powerful natural brain chemicals that support: Memory and Mood; Mental clarity; Concentration; Alertness and Focus.
  
Why buy all the individual herbs and nutrients separately -- at great expense -- when you can buy this excellent combination? The herbs in Mind Power Rx include: Ashwagandha, Bacopa, Fo-Ti, Ginkgo biloba,  Ginseng, Gotu kola, Mucuna pruriens, Reishi, and Rhodiola.  The nutrients and vitamins in Mind Power Rx include Acetyl l carnitine, Carnitine, Carnosine, Choline, DMAE, Inositol, Methylcobalamin, Pantothenic acid, Trimethylglycine, Tyrosine, and Vinpocetine.

Acetyl l carnitine vs l carnitine -- l carnitine and acetyl l carnitine
Q. What's the difference between acetyl l carnitine and l carnitine
   Those who take carnitine pills notice an increase in physical energy, but not as much mental energy. Acetyl l carnitine has a significantly more immediate and noticeable mental effect than carnitine because it crosses into the brain much better. The mind boosting effect of acetyl l carnitine is often noticed within a few hours, or even within an hour. Most people report feeling mentally sharper, having more focus and being more alert. Some find a mild mood enhancement.

Acetyl l carnitine dosage - acetyl l carnitine side effects
The typical daily dosage for long term use is 100 to 300 mg once a day, preferably in the early part of the day. Acetyl l carnitine side effects include overstimulation, insomnia, and nausea at dosages greater than 500 mg to 1000 mg. If you happen to feel nausea as a side effects of acetyl l carnitine, next time just take the acetyl-l-carnitine with food or take a lesser dose.
   Acetyl l carnitine 500 mg is the most common dosage you will find over the counter. Other popular dosages include acetyl l carnitine at 250 mg and 300 mg. For many people, acetyl l carnitine 500 mg may be too high a dose.

Potential Acetyl l Carnitine Benefits according to published studies:
Acetyl l carnitine may benefit those with mental fatigue associated with chronic fatigue syndrome.

Patients with multiple sclerosis may benefit from acetyl carnitine, which could reduce their fatigue.

In aging rats, chronic administration of acetyl carnitine increases cholinergic synaptic transmission and consequently enhances learning capacity. The memory of aging rats is rejuvenated by giving them a combination of acetyl l carnitine and alpha lipoic acid.

Acetyl l carnitine may benefit those with diabetic neuropathy. This nutrient could be helpful in chemotherapy induced peripheral neuropathy.

May reduce alcohol-induced cellular damage to organs.

Acetyl l carnitine may benefit geriatric patients with mild depression.

Acetyl l carnitine improves the function of mitochondria, the organelles within cells that are involved in energy production.

Is more effective than tamoxifen in the therapy of acute and early chronic Peyronie's disease.

Acetyl l carnitine may benefit individuals with degenerative cerebellar ataxia.

Acetyl carnitine is suitable for clinical use in the reduction of neuronal death after peripheral nerve trauma.

May be helpful in those with Alzheimer's disease.
Acetyl l carnitine protects against amyloid-beta neurotoxicity.

L-acetylcarnitine and ADHD
L-acetylcarnitine may help with attention deficit hyperactivity disorder (ADHD) in children with the genetic disorder known as fragile X syndrome. Fragile X syndrome results from an inherited genetic defect on the X chromosome. It is associated with  mental retardation and may also cause autism and ADHD, ADHD is common in young boys with fragile X syndrome. Dr. Giovanni Neri from Universita Cattolica in Rome studied boys between 6 and 13 years old for a period one year. Twenty four received l-acetylcarnitine and 27 received placebo. There was a more effective reduction of hyperactivity and improvement of social behavior in patients treated with acetylcarnitine. American Journal of Medical Genetics 2008.

Acetyl l carnitine and fibromyalgia
Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients.
Clin Exp Rheumatol. 2007 Mar-April Rossini M, Di Munno O, Valentini G, Bianchi G, Biasi G, Cacace E, Malesci D, La Montagna G, Viapiana O, Adami S. Rheumatology Unit, University of Verona, Italy.
One hundred and two patients meeting the American College of Rheumatology criteria for fibromyalgia syndrome were randomized into the study. The treatment consisted of 2 capsules/day of 500 mg acetyl l-carnitine or placebo plus one intramuscular (i.m.) injection of either 500 mg acetyl l-carnitine or placebo for 2 weeks. During the following 8 weeks the patients took 3 capsules daily containing either 500 mg acetyl l-carnitine or placebo. The patients were seen during treatment after 2 (visit 3), 6 (visit 4) and 10 weeks (visit 5). The patients were also visited 4 weeks after treatment discontinuation (follow-up visit).  The "total myalgic score" and the number of positive tender points declined significantly and equally in both groups until the 6th week of treatment. At the 10th week both parameters remained unchanged in the placebo group but they continued to improve in the acetyl l-carnitine group with a statistically significant between-group difference. Although this experience deserves further studies, these results indicate that acetyl l-carnitine may be of benefit in patients with fibromyalgia, providing improvement in pain as well as the general and mental health of these patients.

Acetyl l carnitine and weight loss
High dosages of acetyl l carnitine may help reduce appetite, but a more effective product for appetite suppression and weight loss is Diet Rx.

Forms of Acetyl l Carnitine
You may come across other forms of acetyl carnitine such as acetyl l carnitine arginate. We are not certain whether acetyl l carnitine arginate offers any advantages over acetyl carnitine. Time will tell.

Q. I have been getting email promotions regarding the benefits of acetyl l carnitine arginate. Have there been studies with acetyl l carnitine arginate that show it to be superior to acetyl l carnitine?
   A. As of 2008, we are not aware of human studies comparing acetyl l carnitine to acetyl l carnitine arginate. Acetyl l carnitine supplements work quite well to improve mental function, we are not sure if the arginate form adds any additional benefits.

Q. Is acetyl l carnitine hcl different than plain acetyl l carnitine?
   A. We have no reason to believe acetyl l carnitine hcl has properties different than that of acetyl l carnitine.

Q. I have sometimes seen acetyl l carnitine with an n added before it, n acetyl l carnitine. Is there a difference between the two?
   A. N acetyl l carnitine and acetyl l carnitine are the same supplement.

Acetyl l carnitine and alpha lipoic acid
Some dietary supplements include a combination of acetyl l carnitine and alpha lipoic acid. Although the combination of these two nutrients could be healthy, many acetyl l carnitine and alpha lipoic acid products have too high dosages of these nutrients and side effects could occur. We suggest using no more than 100 mg of acetyl l carnitine and no more than 20 mg of alpha lipoic acid when combining the two for long term use.

Q. I bought a product that had alpha lipoic acid acetyl l carnitine in a dosage of 100 mg and 500 mg. Is this too high a dosage?
   A. Yes, this alpha lipoic acid acetyl l carnitine combination could lead to overstimulation and insomnia.

Acetyl l Carnitine Studies
Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy.
Urology. 2005 Nov;66(5):1080-5.
Operative Unit of Andrology, Societa Italiana di Medicina della Riproduzione, Bologna, Italy.
To determine whether propionyl-L-carnitine (PLC) plus acetyl-L-carnitine improve the effectiveness of sildenafil in restoring sexual potency after bilateral nerve-sparing radical retropubic prostatectomy. We analyzed the data from 96 patients who had undergone bilateral nerve-sparing radical retropubic prostatectomy: 33 were given placebo (group 1), 32 used PLC 2 g/day plus acetyl-l-carnitine 2 g/day plus sildenafil 100 mg when needed (group 2), and 35 used sildenafil alone (group 3). Placebo proved ineffective and sildenafil and sildenafil plus acetyl-l-carnitine and PLC proved effective. The International Index of Erectile Function-15 scores of the group 2 patients were significantly greater than those of group 3 in the following domains: erectile function, sexual intercourse satisfaction, orgasm, and general sexual well-being. The drugs did not significantly modify the score in the sexual desire domain or in the peak systolic velocity or end-diastolic velocity of the cavernosal arteries. Acetyl-l-carnitine plus propionyl-L-carnitine did not significantly improve the side effects of sildenafil. Propionyl-L-carnitine and acetyl-l-carnitine proved to be safe and reliable in improving the efficacy of sildenafil in restoring sexual potency after bilateral nerve-sparing radical retropubic prostatectomy.

Various Forms of Acetylcarnitine provided by Sigma Tau corp:
There are
Acetyl L-Carnitine Hydrochloride
Acetyl L-Carnitine Galactarate (US PATENT 5952379)
Acetyl L-Carnitine Arginate Dihydrochloride
Acetyl L-Carnitine Taurinate Hydrochloride
Acetyl L-Carnitine Hydrogen Fumarate
Acetyl L-Carnitine L-Leucinate Hydrochloride
Acetyl L-Carnitine L-Ornithine Dihydrochloride
     There has not been enough research with each of these forms of acetyl carnitine to determine which are best for long term human consumption.
 

Acetyl-l-carnitine emails
Q. I was wondering what is the difference between Acetylcarnitine and Acetyl-l-carnitine? Is one better then the other in terms of mind boosting ?
   A. They are both the same thing, just a different spelling.

Q.  I am wondering if Acetyl-l-carnitine has any negative sexual drive affect?
   A. Not that we are aware of. If anything, acetyl-l-carnitine should enhance sexuality.

Q. I am using your company's product acetyl-l-carnitine. I am having good results after using for 3 weeks. Is it safe to take this supplement at 200-300mg daily around 5 times/week in the long run.
   A. We prefer that individuals take breaks from supplement use, including acetyl-l-carnitine and the length of breaks is an individual matter. 

Q.
I have been a good customer of my local health food store over the years. I have purchased scores of vitamins/minerals/amino acids and herbs of all types. Mostly I buy herbs for energy as well as anti-oxidants to treat a rare disease that I have. I usually end up throwing away most of them after a couple of weeks use. However, I have been taking Alpha Lipoic Acid and Acetyl-l-carnitine  (500 mg) in the morning on an empty stomach for months now. My mind is clearer, my skin looks better, and my energy level is higher that it has been in years. It also affects my libido in a positive way. I do not work in the nutrition industry. Someone could argue this could be some sort of placebo effect, but it has been such a dramatic effect I don’t think that it is placebo effect at all.

Q. Is it okay to take acetyl l carnitine daily for months and years?
   A. I'm not sure if anybody knows the answer to the consequences of chronic acetylcarnitine intake. With acetylcarnitine, as with most supplements, I often recommend taking a break from use once in a while. I would also try to limit acetylcarnitine intake to 300 mg or less a few times a week.

Q. I take acetyl-carnitine ALC occasionally at important days when i need to be alert. When i take dose of around 250mg i get oversimulated, along with headaches. i tried 50-60mg and that works well making me focused and alert but without any side effects.  Do small doses of 50 mg have positive effects too?
   A. Yes, it is best to take amounts of supplements that still work but do not produce side effects. You listed common side effects from acetyl carnitine which include headache, overstimulation, and some people report nausea.

Q. Is it important to take acetyl l carnitine and alpha lipoic acid together?
   A. Both acetyl l carnitine and alpha lipoic acid have health benefits, but they can be taken separately, it is not essential they be taken together.

Q. I an confused. Some websites say acetyl l carnitine supplement should be taken every day, while Dr. Sahelian's website says an acetyl l carnitine supplement does not have to be taken every day.
   A. We feel that it is best to take days off from the use of many supplements. In the case of acetly l carnitine, if this supplement is being used for mental enhancement, one could instead take other brain supplements such as dmae, choline, bacopa, ginkgo, etc, or a combination of small amounts found in a formula such as Mind Power Rx.

Q. What are acetly l carnitine side effects?
   A. Acetyl l carnitine side effects include nausea, restlessness, insomnia, and irritability. We suggest keeping the acetyl carnitine dosage to less than 500 mg a few times a week.

Q. Can you tell me about acetly l carnitine arginate?
   A. We are not familiar with acetly l carnitine arginate research in humans.

Q. Is a benefit of acetyl-l carnitine improved mental energy?
   A. Yes, this is one of the most commonly noticed benefit of acetly-l carnitine, greater mental energy.

Q. How long does the affect last after taking an n acetyl l carnitine supplement?
   A. Most people begin to notice the effect from an acetyl l carnitine supplement after an hour or two, and the effects can last a few hours or all day depending on the acetyl-l carnitine dosage taken.

5htp 5-hpt web site for information on the mental effects of a serotonin booster for sleep and mood balance.
Acetylcysteine antioxidant supplement used to protect the liver from toxic compounds such as acetaminophen
Advance Physician Formulas is a vitamin company that sells high quality supplements formulated by a medical doctor, Dr. Ray Sahelian, M.D. Some of the top selling products include Mind Power Rx which has acetyl l carnitine and several mind boosting and memory improving nutrients and herbs. 

Q. Is acetyl l carnitine powder sold over the counter?
   A. Yes, you can search google for acetyl l carnitine powder, there are several companies that sell it.

Q. What effect does acetyl l carnitine have on brain function?
   A. The effect of acetyl l carnitine on brain include improved alertness, focus, and mood elevation. Acetyl l carnitine may also influence memory function.

Acorus calamus has been used in the ancient systems of medicine for the treatment of various neurological disorders.
Agrimonia eupatoria have long been used for medicinal purposes but human studies are not available to indicate how agrimonia eupatoria would be useful in medical disease conditions.
Agrimonia pilosa has  long been used for medicinal purposes. We cannot find human studies to indicate how Agrimonia pilosa would be useful in health conditions.