Agrimonia pilosa plant has long been used for medicinal purposes. Agrimonia pilosa is a perennial plant native to Northern Asia and Eastern Europe.
Human research
As of April 2010, we did find human studies to indicate how Agrimonia pilosa
herb would be
useful in health conditions.
Composition
This herb has a good content of
Quercetin flavonoid and related chemicals.
Flavonoids include tiliroside, kaempferol 3-O-alpha-L-rhampyranoside, quercetin
3-O-alpha-L-rhampyranoside, quercetin 3-O-beta-D-glucopyranoside, kaempferol
3-O-beta-D-glucopyranoside, kaempferol, apigenin, and luteolin.
Benefit for flu and virus infection
Broad-spectrum antiviral effect of Agrimonia pilosa extract on influenza
viruses.
Microbiol Immunol. 2010 Jan; Department of Biotechnology, College of Life
Science and Biotechnology, Yonsei University, Seoul 120-749.
Influenza virus continues to emerge and re-emerge, posing new threats for
humans. Here we tested various Korean medicinal plant extracts for potential
antiviral activity against influenza viruses. Among them, an extract of
Agrimonia pilosa was shown to be highly effective against all three subtypes of
human influenza viruses including H1N1 and H3N2 influenza A subtypes and
influenza B virus. The EC(50) value against influenza A virus, as tested by the
plaque reduction assay on MDCK cells, was 14-23 mug/ml. The extract also
exhibited a virucidal effect at a concentration of 160-570 ng/ml against
influenza A and B viruses when the viruses were treated with the extract prior
to plaque assay. In addition, when tested in embryonated chicken eggs the
extract exhibited a strong inhibitory effect in ovo on the H9N2 avian influenza
virus at a concentration of 280 ng/ml. Quantitative RT-PCR analysis data showed
that the extract, to some degree, suppressed viral RNA synthesis in MDCK cells.
HI and inhibition of neuraminidase were observed only at high concentrations of
the extract. And yet, the extract's antiviral activity required direct contact
between it and the virus, suggesting that its antiviral action is mediated by
the viral membrane, but does not involve the two major surface antigens, HA and
NA, of the virus. The broad-spectrum antiviral activity of Agrimonia pilosa
extract on various subtypes of influenza viruses merits further investigation as
it may provide a means of managing avian influenza infections in poultry farms
and potential avian-human transmission.
Acetylcholinesterase inhibition by
compounds in Agrimonia pilosa
Acetylcholinesterase inhibition by flavonoids from
Agrimonia pilosa.
Molecules. 2007 Sepember. Jung M, Park M. Department of Chemistry, Yonsei
University, Seoul 120-749, Korea.
In a bioassay-guided search for acetylcholinesterase inhibitors from 180
medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa
ledeb yielded tiliroside, 3-methoxy quercetin, quercitrin and quercetin. We
report herein for the first time that all four flavonol compounds showed
significant inhibitory effects on acetylcholinesterase, particularly quercetin,
which showed twice the activity of dehydroevodiamine.
Chemical composition of
Agrimonia pilosa
herb
The Agrimonia pilosa herb has a number of flavonoids such as quercetin catechin,
hyperoside, quercitrin, and rutin.
Agrimonia species
Agrimonia eupatoria
Agrimonia pilosa
Agrimonia procera
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